2-HydroxyMethyl-pyrrolidine-1-carboxylic acid benzyl ester - Names and Identifiers
2-HydroxyMethyl-pyrrolidine-1-carboxylic acid benzyl ester - Physico-chemical Properties
2-HydroxyMethyl-pyrrolidine-1-carboxylic acid benzyl ester - Introduction
Cbz-DL-Prolinol(Cbz-DL-Prolinol) is an organic compound, also known as N-protected DL-prolinol. The following is a description of its nature, use, preparation and safety information:
Nature:
- Cbz-DL-Prolinol is a white or almost white crystal with a high melting point and low solubility.
-It is an amine compound with a protecting group (N-double protection is applied).
-Under conventional experimental conditions, it is stable.
Use:
- Cbz-DL-Prolinol are important intermediates in organic synthesis and are used to synthesize drugs and natural products.
-It is often used to protect the amino group in the carboxylic acid compound or the hydroxyl group in the carbonate, so as to prevent the wrong reaction in the reaction process.
-It can also be used for catalyst synthesis and chiral separation reactions.
Preparation Method:
-A commonly used preparation method is to add chloromethyl benzyl carbonate (Cbz-Cl) to DL-prolinol and dimethylformamide (DMF) in a solvent such as Cbz-DL-Prolinol, and under appropriate reaction conditions.
Safety Information:
-The toxicity of Cbz-DL-Prolinol is relatively low, but it is still necessary to take appropriate laboratory safety measures in operation.
-Wear appropriate protective gloves, goggles and lab coats to avoid direct contact with skin and eyes during use.
-The dust or solution of this compound may be irritating to the respiratory tract and digestive tract, so avoid inhalation and ingestion.
-When using or handling, appropriate laboratory operating procedures should be followed to ensure the safety of personnel and the safety of the laboratory.
Last Update:2024-04-09 20:49:11